Liaoyi (Luis) Xu


About

I am a Ph.D. student in Bioinformatics and Computational Biology at the University of Texas at Austin, where I work with Arbel Harpak. I am also completing an M.S. in Statistics at UT Austin. My research sits at the intersection of statistical genetics, machine learning, and population genetics, with a focus on how evolutionary forces and genetic architecture shape complex traits in humans.

I am especially interested in building statistical and computational methods that can recover signals missed by standard analyses, and in using large-scale genetic and sequencing data to better understand selection, sex differences, and disease risk.

Some questions I am especially interested in:

  • how to infer selection acting on duplicated genes from modern sequencing data
  • how sex-specific and dominance effects shape complex trait variation
  • how machine learning can help connect human genetics, evolution, and disease risk

Previously, I earned my master's degree from Zhejiang University, where I studied invertebrate innate immunology.

You can also find my CV and Bluesky here.

Portrait of Liaoyi Xu

News

2026 I received the Graduate Research Recognition Fellowship ($3,000)!
2026 I received the UT Austin Outstanding Graduate Research Fellowship ($38,000)!
2026 “Escape from X inactivation drives sex differences and female trait variation” has been published in Molecular Biology and Evolution!
2026 I placed third at the UT Austin Energy AI Hackathon!
2025 “The genetic architecture of and evolutionary constraints on the human pelvic form” has been published in Science!
2023 I was named a finalist for the ASHG Charles Epstein Award (18 out of 1000+)!
2023 I received the American Chinese Geneticist Association (ACGA) Trainee Award!

Selected Publications

The genetic architecture of and evolutionary constraints on the human pelvic form
Liaoyi Xu, Eucharist Kun, Devansh Pandey, Joyce Y. Wang, Marianne F. Brasil, Tarjinder Singh, and Vagheesh M. Narasimhan
Science, 2025
Escape from X inactivation drives sex differences and female trait variation
Carrie Zhu*, Liaoyi Xu*, and Arbel Harpak
Molecular Biology and Evolution, 2025